Broad Institute

We are seeking an energetic and motivated scientist to be part of CDoT’s in vitro affinity reagent platform. The ideal candidate will have experience with affinity reagents (antibodies, scFvs, or nanobodies, etc) ideally across different display technologies (phage, yeast, ribosome) coupled with a passion for technology development and a strong desire to work at scale with automation, with a keen appreciation for operational efficiency. This position will be part of the team responsible for executing on the development of a high throughput version of our affinity reagent platform. The successful candidate will work closely with antibody engineers, automation engineers, biophysicists, data scientists, machine learning engineers, and Subject Matter Experts to align and execute on platform goals. This position is a unique opportunity to help build a high-impact capability within the Broad. PRINCIPAL DUTIES AND RESPONSIBILITIES Essential Functions Designs and executes on, with supervision, the scientific implementation of high throughput in vitro affinity reagent generation as a platform product within CDoT, including, affinity reagent identification and generation and production and characterization of affinity reagents (binding affinity, epitope binning, and functional characterization) Helps plan, schedule, and coordinate the affinity reagent production process development Identifies technical and methodological problems in the affinity reagent scientific protocol and production process. Makes detailed observations, analyzes/documents experimental data, and interprets results Ensures platform scientific performance adheres to rigorous standards for reproducibility; tracks and communicates metrics of platform performance Presents results to affinity reagent platform leadership Contributes to scientific papers, reports, and presentations. Keeps current on advances in the field of affinity reagent generation and prediction Trains, supervises, and mentors junior members of the platform team MINIMUM QUALIFICATIONS Required Qualifications BS/BA degree in Molecular or Cellular Biology or related field with 6+ years of experience or M.S with 4+ years of experience Experience in affinity reagent discovery and/or engineering Experience in biophysical and cellular characterization of affinity reagents Strategic mindset and desire to constantly improve the status quo Strong analytical skills and the ability to work both independently and as part of a multidisciplinary team Adept in ambiguous situations, flexible and comfortable making decisions using available data points that can be limited or imperfect Adaptable to changing priorities while effectively managing multiple commitments Outstanding interpersonal and communication skills with proven expertise in cultivating cross-collaborative working relationships across an organization and ability to influence at all levels