Broad Institute

The Chen Lab at the Broad Institute of MIT and Harvard develops and applies next‑generation technologies to sequence the genome, epigenome, and transcriptome in situ at single‑cell resolution. We are seeking an exceptionally creative, self‑directed research associate to (1) scale spatial genomic pipelines and (2) manage and collect data across spatial genomics projects. You will design and execute your own experiments, engineer new solutions to technical hurdles, and help shape the lab’s infrastructure and culture.

Why Join Us?
• Cutting‑edge science – Work at the interface of microscopy, genomics, and cancer biology.
• Growth & visibility – Publish, present, and gain broad recognition for your contributions.
• Collaborative culture – Join a supportive, high‑energy team that values mentorship, transparency, and having fun together.
• Broad Institute benefits – Weekly scientific seminars, tuition reimbursement, excellent health coverage, gym access, generous parental leave, and more.

Key Responsibilities

• Execute cutting‑edge spatial genomics assays: Perform and troubleshoot Slide‑tags, Slide‑seq, and related in situ imaging or sequencing workflows.
• Drive experimental design and data generation: Collaborate with lab members to plan, optimize, and run experiments that advance shared project goals.
• Interpret data and the literature: Critically evaluate primary papers and your own results to propose rigorous follow‑up studies or protocol refinements.
• Communicate findings clearly: Maintain detailed digital lab notebooks; distill results into concise slide decks or written reports for individual check‑ins and full‑lab meetings.
• Coordinate priorities and timelines: Partner with the PI and senior scientists to align experimental milestones with overall project strategy, adjusting plans as needed.
• Keep projects on track: Develop and update an organizational roadmap (tasks, reagents, data, and deadlines) to ensure timely, high‑quality completion of all objectives.

Minimum Qualifications

• Education – B.S. or M.S. in Biology, Bioengineering, Biochemistry, Molecular Biology, or a closely related field.
• Laboratory experience – ≥ 2 years of full‑time research experience with hands‑on proficiency in at least one of the following: single-cell transcriptomic workflows; fluorescence or confocal microscopy and basic image analysis; NGS library preparation and molecular‑biology techniques.
• Data skills – Familiarity with Python, MATLAB, R or sequencing‑data analysis, or a demonstrated willingness to learn.
• Problem‑solving ability – Proven track record of independently troubleshooting experiments and proposing creative technical solutions.
• Project management & communication – Excellent organizational, written, and verbal skills; ability to juggle multiple projects, set priorities, and meet deadlines in a fast‑paced, team‑oriented environment.