Broad Institute

The mission of the Broad Institute is to transform medicine by dramatically accelerating the understanding and treatment of disease. The Broad creates a vibrant research environment with close links to top academic institutions including Harvard, MIT and the Harvard hospitals. The Cancer Dependency Map (DepMap) is a large-scale effort in the Cancer Program to identify cancer therapeutic targets systematically.

We seek an energetic and motivated individual to join the DepMap team to lead projects on identifying novel therapeutic targets in the cancer resistance setting. As part of this effort, you will develop novel models, apply novel screening modalities, and collaborate with computational scientists to analyze the data. You might supervise one or more research associates to support the project goals. You will join an experienced team of experimental scientists, project managers, and computational biologists working together to transform precision cancer medicine. The ideal candidate must have expertise in cancer genomics, familiarity with CRISPR screening, and the ability to work within a cross-functional project team. The successful candidate will work independently in a fast-paced, innovative environment. This position offers the exciting opportunity to join a rapidly growing research effort with the ambitious goal of mapping the vulnerabilities of all human cancers.

This role provides a career opportunity to develop into a leader in cancer genomics and learn about large-scale approaches, functional genomics, and target identification. The position also offers ample opportunities to interact with academic and industry partners.

CHARACTERISTIC DUTIES INCLUDE

• Working as part of a dedicated team to develop systematic approaches to cancer target identification.
• Developing and deploying established and novel genome-scale CRISPR screens and other large-scale screening approaches.
• Using systematic approaches to develop models of cancer resistance.
• Performing cell culture and additional molecular biology procedures, including DNA or RNA isolation, PCR, molecular cloning, bacterial expansion, and Western blotting.
• Supervising junior team members.
• Implement experiments to address specific questions to understand genetic dependencies in cancer.
• Creating, monitoring, and implementing effective plans.
• Generating oral and written presentations on performed experiments and presenting results at team meetings.
• Participating in scientific conferences and contributing to peer-reviewed scientific publications.
• Serving as a subject matter expert in engaging internal and external research collaborators.

MINIMUM QUALIFICATIONS

• PhD in cancer biology or related field with 2+ years of job experience.
• Hands-on experience in cell line engineering, functional genomics, single-cell RNAseq, high-throughput microscopy, or NGS-based assays.
• Scientific knowledge of cancer biology and cancer genomics.
• Strong project management skills to support driving initiatives.
• Ability to lead as well as be part of the team and able to work in a fast-paced environment with minimal oversight.
• Highly self-motivated and enthusiastic.
• Strong interpersonal skills and communication as well as relationship management.
• Ability to drive consensus across diverse stakeholders to achieve goals

PREFERRED

• Experience in academic and industry collaborations.
• Familiarity with analysis of CRISPR screens or other large-scale datasets