Broad Institute

We're looking for a passionate and skilled Cell Biologist with High Throughput Screening experience to join our CDoT Collaborative Screening team. Reporting to an Associate Director, you'll be a key member of our multidisciplinary teams, helping to drive the development and execution of predominantly cell-based high throughput screens. Your work will directly empower target validation, assay development, hit discovery and validation. Ideally, you have experience with a variety of assay formats within a drug discovery or therapeutics context.

Key Responsibilities
● Independently design and execute cell-based assays for drug discovery projects, including both genetic and small molecule screening in various high throughput formats.
● Culture and maintain diverse cell lines and primary cells with a high degree of precision.
● Collaborate, coordinate and communicate with cross-functional teams to advance therapeutic projects and ensure that research plans, timelines, and deliverables are met.
● Analyze, interpret, explain and present experimental data, research plans and results to both internal teams and external collaborators.
● Innovate new cellular assay methods and contribute to a fast-paced, dynamic research environment.
● Supervise, train and mentor junior members of the team.

Qualifications
Required Qualifications:

·      Ph.D. with 1-2 years experience in cell biology, chemical biology, or high throughput screening

·      Demonstrated in-depth experience in culturing, deriving, and maintaining various cell lines.

·      Proven ability to work both collaboratively within a team and independently to meet project goals; makes data-driven decisions for forward progress

·      Maintain detailed experimental records, documentation, and written protocols

·      Excellent communication, organization, and time management skills.

·      Must show strong ability to be flexible, to adapt and effectively manage changes in a fast-paced dynamic environment and troubleshoot.

Preferred Qualifications:

·      Experience with the development and execution of plate-based assays, such as Cell Titer-Glo viability assay, immunofluorescence staining and biochemical assays, as well as high-throughput screening and automation.

·      Experience with advanced techniques such as high-content imaging or molecular biology (e.g., qPCR, western blotting, ELISA).

·      Experience with FLIPR (Fluorescence Imaging Plate Reader) assays to measure intracellular calcium flux, membrane potential, and ion channel activity.

·      Ability to mentor junior trainees