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General information

Location
Cambridge, MA
Ref #
40041
Job Family
Research
Workplace
On-Site
Date published
31-May-2024
Time Type
Full time

Description & Requirements

The Stanley Center therapeutics group is seeking a candidate that will support the in vitro characterization of novel therapeutics developed here at the Broad Institute to treat the unmet needs of schizophrenia. The position will be embedded within the Stanley Center therapeutics group that combines genetics, medicinal chemistry, and high-throughput technologies with animal model systems. The Broad Institute provides a vibrant research environment with close links to MIT, Harvard, and the Harvard-affiliated hospitals across Boston. The candidate will work with senior researchers to develop, validate, and subsequently perform cell-based in vitro assays to characterize the effects of novel small molecule compounds targeting schizophrenia risk genes and associated pathways. The candidate will interact intensively with a range of biologists, electrophysiologists, chemists, and computational scientists. The candidate will spearhead the following projects:

CHARACTERISTIC DUTIES

  • Perform in vitro screening using high throughput assays to evaluate novel small molecules that target ion channels, GPCRs and other druggable proteins relevant for schizophrenia and other psychiatric disorders
  • Attend and present at multidisciplinary team meetings to share results, plan projects and experiments, and ensure that projects support team goals and contribute to scientific publications
  • Troubleshoot to resolve problems and participate in new technology evaluation, development, and implementation
  • Document, compile, and analyze experimental data
  • Maintain detailed experimental records, documentation, and written protocols
  • Attend and present at Stanley Center and Broad-wide presentations
  • May perform other duties as assigned

QUALIFICATIONS

  • B.S. in biology, neurobiology, chemistry, molecular/cellular biology, or a related field, with at least 4 years of in vitro cell culture experience required.
  • Prior neuroscience research experience required
  • Prior experience performing high throughput in vitro assays is strongly desired
  • Experience in generation of stable cell lines preferred
  • Experience with molecular biology (nucleic acid/protein isolation, qPCR, western blot) preferred
  • Outstanding personal initiative and communication skills
  • Any electrophysiology experience strongly preferred
  • Must be able to work independently and on multidisciplinary project teams
  • Exceptional organizational and time management skills, lab notebook practices, and attention to detail
  • Curiosity to learn new things and a passion to make a difference in the lives of people with mental illness by advancing novel treatments for psychiatric diseases.
  • Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems

The Stanley Center therapeutics group is seeking a candidate that will support the in vitro characterization of novel therapeutics developed here at the Broad institute to treat the unmet needs of schizophrenia. The position will be imbedded within the Stanley Center therapeutics group that combines genetics, medicinal chemistry, high-throughput technologies with animal model systems. The Broad Institute provides a vibrant research environment with close links to MIT, Harvard, and the Harvard-affiliated hospitals across Boston. The candidate will work with senior researchers to develop, validate, and subsequently perform cell based in vitro assays to characterize the effects of novel small molecule compounds targeting schizophrenia risk genes and associated pathways. The candidate will interact intensively with a range of biologists, electrophysiologists, chemists, and computational scientists. The candidate will spearhead the following projects:

CHARACTERISTIC DUTIES

• Perform in vitro screening using high throughput assays to evaluate novel small molecules that target ion channels, GPCRs and other druggable proteins relevant for schizophrenia and other psychiatric disorders
• Attend and present at multidisciplinary team meetings to share results, plan projects and experiments, and ensure that projects support team goals and contribute to scientific publications
• Troubleshoot to resolve problems and participate in new technology evaluation, development, and implementation
• Document, compile, and analyze experimental data
• Maintain detailed experimental records, documentation, and written protocols
• Attend and present at Stanley Center and Broad-wide presentations
• May perform other duties as assigned

QUALIFICATIONS

• B.S. in biology, neurobiology, chemistry, molecular/cellular biology or a related field, with at least 2 years of in vitro cell culture experience required.
• Prior experience performing high throughput in vitro assays strongly desired
• Experience in generation of stable cell lines preferred
• Experience with molecular biology (nucleic acid/protein isolation, qPCR, western blot) preferred
• Outstanding personal initiative and communication skills
• Any electrophysiology experience strongly preferred
• Must be able to work independently and on multidisciplinary project teams
• Exceptional organizational and time management skills, lab notebook practices and attention to detail
• Curiosity to learn new things and a passion to make a difference in the lives of people with mental illness by advancing novel treatments for psychiatric diseases.
• Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems

Job Description