Broad Institute

Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients. We also create new technologies and work to combine the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community.

Position Summary:
We are currently seeking a highly motivated and passionate bench-based research associate to support several early drug discovery projects in medicinal chemistry. We will provide professional medicinal chemistry training to support the candidate in driving therapeutic discovery at the bench through the synthesis and isolation of novel therapeutic targets. The successful candidate will have extensive experience with modern synthetic, purification techniques and characterization of small molecules. Experience in medicinal chemistry is required, preferably in an industrial, lab-based setting.


Key Responsibilities

·      Independently design synthetic routes, synthesize, isolate, and purify novel small molecules to advance ongoing projects.

·      Support and troubleshoot the development of appropriate synthetic routes to deliver compounds to allow for the understanding of structure activity relationships (SAR) across different scaffolds.

·      Document work in electronic notebooks in a timely fashion

·      Manage, analyze, and effectively present results to multi-disciplinary project teams

·      Work in partnership with team members and collaborators to deliver on project goals and milestones.

QUALIFICATIONS

·      BA/BS in chemistry or a closely related field with 4+ years postgraduate organic chemistry / medicinal chemistry research experience OR MS in chemistry or a closely related field with 2+ years organic chemistry / medicinal chemistry research experience in an academic or industrial setting (industrial setting preferred).

·      Experience and track record of success with multistep chemical synthesis

·      Record of successful delivery on new synthetic routes and the application of those to the rapid delivery of synthetic intermediates and novel target small molecules

·      Experience with modern normal phase, reverse phase, and HPLC purification techniques, as well as analysis of LCMS and NMR spectra to support compound characterization.

·      Proven track record of successful completion of compound syntheses including independent troubleshooting problematic routes and delivery of required compounds in suitable yield and purity.

·      A record of successful communication and interaction with project team members, external customers, or vendors is advantageous

The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.