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General information

Location
Burlington, MA
Ref #
43028
Job Family
Research
Workplace
On-Site
Date published
26-Sep-2025
Time Type
Full time

Description & Requirements

Company Overview: Broad Clinical Labs (BCL), a CLIA-licensed and CAP-accredited wholly owned subsidiary of the Broad Institute, offers services to power your multi-omic data generation and analysis needs, across a range of research, translational, and clinical Dx applications.

Position Summary:  At Broad Clinical Labs (BCL), a CLIA-licensed and CAP-accredited subsidiary of the Broad Institute, we specialize in multi-omic data generation for research, translational, and clinical applications. This role offers a unique opportunity to join our Contract Assay Services (CAS) team and directly impact patient care.

Your work will center on a rapid Clinical Metagenomic Next Generation Sequencing (cmNGS) assay that delivers critical results for patients suspected of meningitis or encephalitis in under 36 hours. As our team expands, we are seeking a self-motivated, task-oriented Process Development Associate I with strong critical-thinking skills. The ideal candidate will thrive on upholding operational excellence in the cmNGS lab while driving the continuous improvement and development of both new and existing clinical assays.

Work Schedule: This is a full-time role with core hours from 8:00 AM to 4:30 PM. Due to the fast-paced nature of this work, the successful candidate must have the flexibility to work on weekends and outside of standard hours as needed


Key Responsibilities:
  • Perform end-to-end sample processing for the clinical metagenomic Next-Generation Sequencing (cmNGS) assay, from sample receipt to library preparation and sequencer loading, utilizing both manual and automated laboratory techniques.
  • Support daily operations of the cmNGS workflow, ensuring all procedures are performed according to established Standard Operating Procedures (SOPs).
  • Monitor key performance indicators (KPIs) and quality control (QC) metrics to ensure the process remains in a state of control. Promptly escalate any deviations or out-of-spec results.
  • Accurately record and update information in our Laboratory Information Management System (LIMS) and Quality Management Systems , including routine entries such as instrument maintenance logs, reagent usage and inventory tracking, and training records while following established procedures and compliance requirements.
  • Actively participate in troubleshooting instrument and assay issues, collaborating with team members and support groups to identify root causes and implement corrective actions.
  • Assist in the execution of validation and verification studies for new instruments, reagents, or process improvements under the guidance of senior staff.
  • Ensure clear and consistent communication with team members across shifts and with other functional groups to facilitate a smooth and efficient workflow.


Required Qualifications & Skills:
  • Bachelor of Science in Biology, Molecular Biology, Chemistry, or a related life science field.
  • Minimum of 1 year of hands-on experience in a high-complexity, CLIA-certified clinical laboratory.


Preferred Qualifications:
  • Direct experience with core molecular biology techniques
  • Excellent verbal and written communication abilities
  • Strong organizational skills with a keen attention to detail
  • Strong critical thinking and problem-solving abilities with a proactive approach to identifying and addressing potential issues.
  • Ability to work both independently and collaboratively within a fast-paced, team-oriented environment.
  • Hands-on experience with Next-Generation Sequencing (NGS) workflows and platforms (e.g., Illumina) is highly desirable.
  • Experience with automated liquid handling systems (e.g., Hamilton, Bravo).
  • Familiarity with LIMS and electronic Quality Management Systems 
  • Strong analytical skills with proficiency in Excel or JMP