Broad Institute

We are seeking to hire a postdoctoral associate to join the Broad Institute and Massachusetts General Hospital to be co-mentored by Dr. Mark Daly and Dr. Ramnik Xavier. In this role, the postdoc will lead the development and application of novel methods for the integration of multimodal biological datasets to understand how common and rare variants associated to autoimmune disease and neurodegenerative disease contribute to etiology. The candidate should have a strong computational background and knowledge of statistical methods, as well as demonstrated expertise in large scale data processing and analysis, and be motivated to leverage genomics to understand disease pathology. A successful candidate is expected to excel at critical thinking and be a keen learner for new computational tools and analytical approaches. The postdoctoral trainee should be self-motivated and willing to take advantage of the multidisciplinary network of scientists around them and engage with collaborators and fellow group members. Characteristic Duties: The overarching goal of the postdoctoral research project will be to leverage multimodal biological datasets to understand how rare and common genetic associations contribute to the etiology. Utilize data derived from CRISPR-I and CRISPR-A experiments to learn the consequences on cellular phenotypes of genetic variants. Leverage cellular phenotypes in single cell expression and apply appropriate statistical tools to examine cellular variation. Develop a computational pipeline that performs efficient and reproducible analysis, including quality control measures. Employ cloud computing resources to perform distributed analyses at scale, through the development of reproducible and well-organized code. Requirements: PhD in statistics, mathematics, genetics, bioinformatics or a closely related field, with solid training in analytical methods. Excellent computational/programming and analytical skills. Fast learner and analytical thinker, comfortable taking initiative to learn new skills and drive projects to completion. Demonstrated experience in statistical research and/or genetics, publication in scientific journals and demonstrated ability to communicate scientific ideas through verbal presentations. Motivation to communicate research findings with the broader field through high- quality publications. Strong communication skills and willingness to engage with other members of the lab and contribute ideas through team meetings and discussions. Applications should be directed to Dr Mark Daly ( mjdaly@broadinstitute.org) and Dr Ramnik Xavier ( rxavier@broadinstitute.org #LI-DNP