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General information

Location
Cambridge, MA
Ref #
39404
Job Family
Research
Date published
17-Jul-2024
Time Type
Full time

Description & Requirements

The Broad

The Broad Institute of MIT and Harvard is one of the world's leading biomedical research institutes. It seeks to discover the molecular basis of major human diseases, develop effective new approaches to diagnostics and therapeutics, and disseminate discoveries, tools, methods, and data openly to the entire scientific community. Founded in 2004, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities, with collaborations spanning the globe. 


Job description

The Macosko lab is seeking an exceptional, highly self-motivated postdoctoral fellow to lead a project analyzing single cell and spatial genomics data from patients with X-linked Dystonia Parkinsonism, a rare genetic neurological disorder.  This work is an extension of our technology development efforts in single cell and spatial transcriptomics methods, which have culminated in a high-throughput pipeline for building high-quality datasets using these technologies on postmortem brain specimens.  Using results from human genetics to inform our analyses of these new datasets, we hope to uncover the pathogenic mechanisms underlying this currently mysterious neurological disorder. The candidate will join a vibrant, multidisciplinary environment of computational biologists, software engineers, molecular neuroscientists, and technology developers.  

Minimum Qualifications

  • Experience analyzing complex, high-dimensional genomics datasets.  A background in neuroscience is not essential.