Broad Institute

The Broad Institute is an amazing place - we apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. Through our partnerships with MIT, Harvard, and the Harvard teaching hospitals, we've become a worldwide hub of cutting-edge biomedical science. 

This is a unique opportunity to join the Chen lab at the Broad Institute who are developing methods for studying differences in developing novel genomic tools for studying the spatial organization of tissues. We operate in a highly collaborative, fast-paced environment, with ample learning and growth opportunities as we build our team. Chen and colleagues have pioneered new techniques for imaging nucleic acids in situ using Expansion Microscopy. We are pioneering tools to perform genomic, epigenomic, and transcriptomic assays together for the first time. These readouts combine microscopy and next generation sequencing readouts, revealing a wealth of information about how the genome, epigenome, and transcriptome are organized in space, and how they work together to produce complex cellular behaviors. 

We are looking for an exceptionally creative and self-motivated individual to join us in developing new methods for studying gene expression across space and time. The successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining molecular biology and microscopy and will work closely with immunologists, computational biologists, chemists, and engineers. Key responsibilities include: Responsible for development, validation, and optimization of novel in situ transcriptomic tools or tools to look at dynamic interactions between cells Development of novel single cell, spatially resolved transcriptomic methods Determine the feasibility and makes recommendations regarding the acquisition and/or implementation of new technologies, reagents, and assay procedures Use demonstrated scientific creativity, collaboration with others, and independent thought to expand technical capabilities and identify new research opportunities 

• Ph.D. in bioengineering, chemical engineering, cell biology or biochemistry or related (a background in microscopy is strongly preferred) 
• Proven ability in molecular biology 
• Experience in next generation sequencing workflow and analysis 
• Strong publication record and excellent communication skills 
• Excellent organization and time management skills 
• Must be able to handle a variety of tasks and to adapt to a highly dynamic environment

 EOE/Minorities/Females/Protected Veterans/Disabilities 

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